AlphaGenome 2: Deciphering how cells read DNA to better understand disease

November 11, 2026 ScienceAlphaGenome 2: Deciphering how cells read DNA to better understand diseaseAdam Gayoso, Natasha Latysheva, Pushmeet Kohli and Žiga Avsec Read the paper Our next-generation DNA sequence model bridges single-cell biology and human genetics, predicting how genetic variants affect hundreds of human cell types.Today, we are announcing AlphaGenome 2, our next-generation model that predicts how DNA sequences and their variations impact specific human cell types, giving scientists a powerful new tool to uncover the cellular drivers of disease.Cells are the building blocks of life. Every cell in our body carries the same DNA blueprint, yet each cell type and state—like a heart muscle cell or an immune cell fighting an infection—switches different genes on or off to do…